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POLICIES AND REGULATIONS FOR PROMOTING MANURE MANAGEMENT FOR SUSTAINABLE LIVESTOCK PRODUCTION IN CHINA: A REVIEW

Sha WEI, Zhiping ZHU, Jing ZHAO, David R. CHADWICK, Hongmin DONG

《农业科学与工程前沿（英文）》 2021年 第8卷 第1期   页码 45-57 doi: 10.15302/J-FASE-2020369

摘要： Livestock numbers in China have more than tripled between 1980 and 2017. The increase in the number of intensive livestock production systems has created the challenges of decoupled crop and livestock systems, low utilization of manures in croplands, and subsequent environmental pollution. Correspondingly, the government has enacted a series of policies and regulations to increase the sustainability of livestock production. This paper reviews the objectives of these policies and regulations and their impacts on manure management. Since 2017 there have been two policy guides to speed up the appropriate use of manures, three action plans for increasing manure recycling, and one technical guide to calculate nutrient balances. Requirements of manure pollution control and recycling for improved environmental performance of livestock production systems were included in three revised environmental laws. Most recent survey data indicate that the utilization of livestock manures was 70% in 2017, including that used as fertilizer and/or for production of energy. The targets for manure utilization are 75% in 2020 and 90% in 2035. To achieve these targets and promote ‘green livestock production’, additional changes are needed including the use of third-party enterprises that facilitate manure exchange between farms and a more integrated manure nutrient management approach.

关键词： integrated crop and livestock production     manure utilization     policy recommendations     sustainability     third-party service contractors    

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Toward resilient cloud warehousing via a blockchain-enabled auction approach

《工程管理前沿（英文）》   页码 20-38 doi: 10.1007/s42524-022-0224-2

摘要： Cloud warehousing service (CWS) has emerged as a promising third-party logistics service paradigm driven by the widespread use of e-commerce. The current CWS billing method is typically based on a fixed rate in a coarse-grained manner. This method cannot reflect the true service value under the fluctuating e-commerce logistics demand and is not conducive to CWS resilience management. Accordingly, a floating mechanism can be considered to introduce more flexible billing. A CWS provider lacks sufficient credibility to implement floating mechanisms because it has vested interests in terms of fictitious demand. To address this concern, this report proposes a blockchain-enabled floating billing management system as an overall solution for CWS providers to enhance the security, credibility, and transparency of CWS. A one-sided Vickrey–Clarke–Groves (O-VCG) auction mechanism model is designed as the underlying floating billing mechanism to reflect the real-time market value of fine-grained CWS resources. A blockchain-based floating billing prototype system is built as an experimental environment. Our results show that the O-VCG mechanism can effectively reflect the real-time market value of CWSs and increase the revenue of CWS providers. When the supply of CWS providers remains unchanged, allocation efficiency increases when demand increases. By analyzing the performance of the O-VCG auction and comparing it with that of the fixed-rate billing model, the proposed mechanism has more advantages. Moreover, our work provides novel managerial insights for CWS market stakeholders in terms of practical applications.

关键词： resilient cloud warehousing     blockchain technology     floating billing management system     auction mechanism     third-party logistics    

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效率不确定下企业物流管理模式的柔性选择研究

张红波,罗一新

《中国工程科学》 2008年 第10卷 第9期   页码 88-91

摘要：

分析了物流管理模式及我国物流管理现状，通过建立模型，采用实物期权分析方法，得到了物流服务效率不确定条件下企业从自营物流管理模式转向采用第三方物流管理模式的门槛值。分析结果表明，自营物流服务的效率、企业原有资产的损失及交易成本的大小、物流服务效率提高速度的快慢与物流服务效率的不确定程度，会对企业物流管理模式的选择产生重要影响。

关键词： 企业物流管理模式     实物期权     自营物流     第三方物流     柔性选择    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 383-388 doi: 10.1007/s11684-016-0488-1

摘要：

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.

关键词： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

《医学前沿（英文）》 2022年 第16卷 第5期   页码 701-713 doi: 10.1007/s11684-022-0951-0

摘要： A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), such as osimertinib, which have shown remarkable success in the treatment of advanced NSCLC with EGFR activating mutations, in order to achieve maximal response duration or treatment remission. Apoptosis is a major type of programmed cell death tightly associated with cancer development and treatment. Evasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquired resistance in cancer therapy. It has been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIs, particularly osimertinib, to exert their therapeutic efficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquired resistance. Hence, restoration of cell sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs.

关键词： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Rethinking the tendering frameworks of construction contractors in the context of a soft systems methodology

Stephen URQUHART, Andrew WHYTE

《工程管理前沿（英文）》 2018年 第5卷 第3期   页码 369-380 doi: 10.15302/J-FEM-2018019

摘要：

Limited research has been conducted on the internal tendering procedures (ITP) of construction contractors because of the commercially sensitive and confidential nature of the subject matter. This limitation explains the reluctance of contractors to undergo interviews. Existing research (outside bid/no-bid and margin decision factor identification and subsequent decision modeling development) only begins to provide insights into key tendering stages, particularly around risk assessments and corporate review processes. Early research suggested one to three review stages. However, when considering the whole work procurement process from prospect identification to contract execution, five to seven series of reviews can be arguably applied by some contractors, wherein some reviews stepped through several layers of internal senior management. Tendering processes were presented as flowchart models that traditionally follow “hard” system (rectangular shapes and straight line arrows) steps, which suggest that a precise process also leads to precise results. However, given that contractors do not win every tender they submit, the process is less precise than that suggested in rigidly structured flowcharts. Twenty-five detailed semi-structured interviews were held with purposely selected high-profile publicly and privately owned construction companies in Australia with significantly varied turnovers. Analyses show that contractors are concerned about the negative effects of increasing corporate governance demands, with many stating that people involved are the most critical element to tendering success. A new way of presenting the ITP of contractors is assessed using a soft systems methodology (SSM) approach. SSM offers an alternative way of considering human interaction challenges within the ITP of contractors, which needs to be tested with the industry. The format graphics of SSM guidelines are presented as a way of offering contractors a different approach, which may assist individuals who are looking to re-structure their tendering activities in a more humanistic and less rigid procedural approach.

关键词： contractor     corporate governance     humanistic     risk     soft systems methodology     tendering procedures    

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Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

《信息与电子工程前沿（英文）》 2018年 第19卷 第4期 doi: 10.1631/FITEE.17e0814

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Should medium-sized contractors still implement home-made information technologies on construction sites

Conrad BOTON, Éric ST-PIERRE, Gabriel LEFEBVRE

《工程管理前沿（英文）》 2020年 第7卷 第1期   页码 142-158 doi: 10.1007/s42524-019-0065-9

摘要： Despite the increasing dissemination of the Building Information Modeling (BIM) approach, many firms are still far from BIM and are only starting to adopt information technologies. We conducted an ethnographic action research with an industrial partner that implements information technologies on its construction sites, with a strong preference for home-made applications. Results show that the development of such applications faces difficulties and that multiple iterations and versions are necessary before achieving the expected goals because the required competencies are lacking among internal development teams. Moreover, initial needs evolve considerably throughout the application’s development and evaluation process. However, notwithstanding the difficulties encountered during the different application development phases, the industrial partner believes the decision to be worthwhile because of the desire to have internal control over the project data and the need to consider certain specificities related to business processes.

关键词： small- and medium-sized enterprises     mobile computing     mobile cloud computing     information technology for construction     construction site     ethnographic action research    

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Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

《机械工程前沿（英文）》 2011年 第6卷 第4期   页码 409-418 doi: 10.1007/s11465-011-0245-8

摘要：

The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order shear deformation theory (TSDT) is studied. The beam is made of laminated composite, and located on a Pasternak viscoelastic foundation. By using the principle of total minimum potential energy, the governing partial differential equations of motion are obtained. The solution is directed to compute the deflection and bending moment distribution along the length of the beam. Also, the effects of two types of composite materials, stiffness and shear layer viscosity coefficients of foundation, velocity and frequency of the moving load over the beam response are studied. In order to demonstrate the accuracy of the present method, the results TSDT are compared with the previously obtained results based on first-order shear deformation theory, with which good agreements are observed.

关键词： timoshenko composite beam     pasternak viscoelastic foundation     third-order shear deformation theory (TSDT)     harmonic moving load    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

《医学前沿（英文）》 2022年 第16卷 第1期   页码 93-101 doi: 10.1007/s11684-021-0914-x

摘要： Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via vaccination is essential to combat the current pandemic of coronavirus disease 2019 (COVID-19). It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time, which calls for an additional vaccination regime, as known as booster immunization, to restore immunity among previously vaccinated populations. Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccine (Vero cell), on 136 participants aged between 18 to 63 years. Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28. While systemic reactogenicity was either absent or mild, SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks, surpassing the peak antibody titers elicited by the initial two-dose immunization regime. Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination. Furthermore, in an exploratory study, a newly developed recombinant protein vaccine, NVSI-06-08 (CHO Cells), was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals. Together, these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity, providing support for further trials of booster vaccination in larger populations.

关键词： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem Regular Papers

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

《信息与电子工程前沿（英文）》 2019年 第20卷 第3期 doi: 10.1631/FITEE.19e0001

摘要： In the original version of this article, there is a mistake about the result of DPCL++ (Isik et al., 2016) in Section 5.6 (Fig. 7). As reported in Isik et al. (2016), the SDR improvement was 10.3 dB, rather than 9.4 dB. For further information, the best performance in Isik et al. (2016) was 10.8 dB with the help of a more complicated architecture.

关键词： None    

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Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

《结构与土木工程前沿（英文）》 2011年 第5卷 第3期   页码 315-322 doi: 10.1007/s11709-011-0117-7

摘要： Load and resistance factors are generally obtained using the first order reliability method (FORM) in which the design point should be determined and derivative-based iterations used. In this article, the third-moment reliability index, based on the three-parameter lognormal (3P-lognormal) distribution, is investigated. A simple method based on the third-moment method for estimating load and resistance factors is then proposed, and a simple formula for the target mean resistance is also presented to avoid iterative computations. Unlike the currently used method, the proposed method can be used to determine load and resistance factors, even when the probability density functions (PDFs) of the basic random variables are not available. Moreover, the proposed method does not require the iterative computation of derivatives or any design points. Thus, the method provides a more convenient and effective way to estimate load and resistance factors in practical engineering applications. Numerical examples are presented to demonstrate the advantages of the proposed third moment method for determining load and resistance factors.

关键词： load and resistance factors     third-moment method     three-parameter lognormal (3P-lognormal) distribution     target mean resistance     simple formula    

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服务供应链的信息共享机制及绩效研究

杨善林,程飞,杨昌辉

《中国工程科学》 2011年 第13卷 第8期   页码 80-86

摘要：

文章研究的服务供应链包含一个服务供应商和一个服务集成商信息共享机制问题。服务供应商提供原始服务产品或活动给服务集成商，而服务集成商依次以附加值集成服务出售给客户。在不确定性市场环境下，客户服务需求量带有价格敏感和随机性的特征。在服务供应商和服务集成商之间，探析服务供应链的不同信息传输方式下信息共享机制问题，评估服务供应链的绩效，其结果强调服务业开展信息共享的必要性。

关键词： service supply chain     service vendor     service integrator     information sharing     coordination    

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第三届全球重大挑战峰会

Bartolomeo Maggie

《工程（英文）》 2017年 第3卷 第4期   页码 434-435 doi: 10.1016/J.ENG.2017.04.018

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Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

《化学科学与工程前沿（英文）》 2021年 第15卷 第1期   页码 127-137 doi: 10.1007/s11705-020-1936-7

摘要： Effects of a benzotriazole (BTA)-based small molecule, BTA2, as the third component on the charge carrier generation and recombination behavior of poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl]thieno[3,4-b]thiophenediyl]] (PTB7):[6,6]-phenyl-C -butyric acid methyl ester (PC BM) organic solar cells (OSCs) were investigated by optical simulation of a transfer matrix model (TMM), photo-induced charge extraction by linearly increasing voltage (photo-CELIV) technique, atomic force microscope (AFM), and the Onsager–Braun model analysis. BTA2 is an A A D A A -type non-fullerene small molecule with thiazolidine-2,4-dione, BTA, and indacenodithiophene as the terminal acceptor (A ), bridge acceptor (A ), and central donor (D), respectively. The short-circuit current density of the OSCs with BTA2 can be enhanced significantly owing to a complementary absorption spectrum. The optical simulation of TMM shows that the ternary OSCs exhibit higher internal absorption than the traditional binary OSCs without BTA2, resulting in more photogenerated excitons in the ternary OSCs. The photo-CELIV investigation indicates that the ternary OSCs suffer higher charge trap-limited bimolecular recombination than the binary OSCs. AFM images show that BTA2 aggravates the phase separation between the donor and the acceptor, which is disadvantageous to charge carrier transport. The Onsager-Braun model analysis confirms that despite the charge collection efficiency of the ternary OSCs being lower than that of the binary OSCs, the optimized photon absorption and exciton generation processes of the ternary OSCs achieve an increase in photogenerated current and thus improve power conversion efficiency.

关键词： third component     organic solar cells     charge carrier generation     charge carrier recombination     bimolecular recombination    

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标题 作者 时间 类型 操作

POLICIES AND REGULATIONS FOR PROMOTING MANURE MANAGEMENT FOR SUSTAINABLE LIVESTOCK PRODUCTION IN CHINA: A REVIEW

Sha WEI, Zhiping ZHU, Jing ZHAO, David R. CHADWICK, Hongmin DONG

期刊论文

Toward resilient cloud warehousing via a blockchain-enabled auction approach

期刊论文

效率不确定下企业物流管理模式的柔性选择研究

张红波,罗一新

期刊论文

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

期刊论文

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

期刊论文

Rethinking the tendering frameworks of construction contractors in the context of a soft systems methodology

Stephen URQUHART, Andrew WHYTE

期刊论文

Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

期刊论文

Should medium-sized contractors still implement home-made information technologies on construction sites

Conrad BOTON, Éric ST-PIERRE, Gabriel LEFEBVRE

期刊论文

Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

期刊论文

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

期刊论文

Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

期刊论文

Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

期刊论文

服务供应链的信息共享机制及绩效研究

杨善林,程飞,杨昌辉

期刊论文

第三届全球重大挑战峰会

Bartolomeo Maggie

期刊论文

Effects of BTA2 as the third component on the charge carrier generation and recombination behavior of

Leijing Liu, Hao Zhang, Bo Xiao, Yang Liu, Bin Xu, Chen Wang, Shanpeng Wen, Erjun Zhou, Gang Chen, Chan Im, Wenjing Tian

期刊论文